Cambridge ( KAYM-brij) is a city in Middlesex County, Massachusetts, United States. As part of the Boston metropolitan area, the city’s population of the 2020 U.S. census was 118,403, making it the fourth most populous city in the state, behind Boston, Worcester, and Springfield. It is one of two de jure county seats of Middlesex County, although the county’s executive government was abolished in 1997. Situated directly north of Boston, across the Charles River, it was named in honor of the University of Cambridge in England, once also an important center of the Puritan theology embraced by the town’s founders.^: 18

Harvard University, the Massachusetts Institute of Technology (MIT), Lesley University, and Hult International Business School are in Cambridge, as was Radcliffe College before it merged with Harvard. Kendall Square in Cambridge has been called “the most innovative square mile on the planet” owing to the high concentration of successful startups that have emerged in the vicinity of the square since 2010.

Native Americans inhabited the area that would become Cambridge for thousands of years prior to European colonization of the Americas. At the time of European contact and exploration, the area was inhabited by Naumkeag or Pawtucket to the north and Massachusett to the south, and may have been inhabited by other groups such as the Totant not well described in later European narratives. The contact period introduced a number of European infectious diseases which would decimate native populations in virgin soil epidemics, leaving the area uncontested upon the arrival of large groups of English settlers in 1630. In 1639, the Massachusetts General Court would purchase the land that would become present day Cambridge from the Naumkeag Squaw Sachem of Mistick.

In December 1630, the site of what would become Cambridge was chosen because it was safely upriver from Boston Harbor, making it easily defensible from attacks by enemy ships. Thomas Dudley, his daughter Anne Bradstreet, and her husband, Simon Bradstreet, were the town’s founders. The first houses were built in the spring of 1631. The settlement was initially referred to as “the newe towne”. Official Massachusetts records show the name rendered as Newe Towne by 1632, and as Newtowne by 1638.

Located at the first convenient Charles River crossing west of Boston, Newtowne was one of several towns (including Boston, Dorchester, Watertown, and Weymouth) founded by the 700 original Puritan colonists of the Massachusetts Bay Colony under Governor John Winthrop. Its first preacher was Thomas Hooker, who led many of its original inhabitants west in 1636 to found Hartford and the Connecticut Colony; before leaving, they sold their plots to more recent immigrants from England. The original village site is now within Harvard Square. The marketplace where farmers sold crops from surrounding towns at the edge of a salt marsh (since filled) remains within a small park at the corner of John F. Kennedy and Winthrop Streets.

In 1636, the Newe College (later renamed Harvard College after benefactor John Harvard) was founded by the Massachusetts Bay Colony to train ministers. According to Cotton Mather, Newtowne was chosen for the site of the college by the Great and General Court (the Massachusetts legislature) primarily for its proximity to the popular and highly respected Puritan preacher Thomas Shepard. In May 1638, the settlement’s name was changed to Cambridge in honor of the university in Cambridge, England.

The town comprised a much larger area than the present city, with various outlying parts becoming independent towns over the years: Cambridge Village (later Newtown and now Newton) in 1688, Cambridge Farms (now Lexington) in 1712 or 1713, and Little or South Cambridge (now Brighton) and Menotomy or West Cambridge (now Arlington) in 1807. In the late 19th century, various schemes for annexing Cambridge to Boston were pursued and rejected.