East Falmouth is a census-designated place (CDP) in the town of Falmouth in Barnstable County, Massachusetts, United States. It is located at the base of Massachusetts’ “fishhook” peninsula (see map at right). The population was 6,038 at the 2010 census, making East Falmouth the most populous of the six CDPs in Falmouth.

East Falmouth is located in the southeastern part of Falmouth at 41°33′54″N 70°33′0″W / 41.56500°N 70.55000°W / 41.56500; -70.55000 (41.565096, -70.549984). It is bordered to the west by the village of Teaticket and to the east by the Childs River. Its southern border is the shore of Vineyard Sound.

According to the United States Census Bureau, the CDP has a total area of 6.3 square miles (16.3 km). 5.4 square miles (14.1 km²) of it is land and 0.85 square miles (2.2 km) of it (13.54%) is water.

South of Massachusetts Route 28, the CDP is split into four necks, separated by tidal creeks (or “ponds”), each neck forming a natural neighborhood within the CDP. From east to west, the neighborhoods are:

Seacoast Shores, formerly known as Jenkin’s Neck, is one of the most densely populated neighborhoods in Falmouth, containing 905 homes. The Seacoast Shores Association is a not-for-profit organization that maintains 22 rights of way and a private beach for association members and residents of the neighborhood.^{[citation needed]}

Great Harbors is a private community located on Lewis Neck north of Acapesket and consisting of 11 streets and almost 400 houses. The Great Harbors Resident Association is a non-profit organization that governs and manages the community, incorporated in December 1966. Great Harbors is a waterfront community, with its longest street on the water, as well as its pool/tennis/recreation complex and two boat docks. Great Harbors is managed by a volunteer board of directors, elected by all members of the association at an annual meeting in June.